diff --git a/src/crypto/cipher_extra/e_chacha20poly1305.c b/src/crypto/cipher_extra/e_chacha20poly1305.c
index 6510ff48a..3ac2af82f 100644
--- a/src/crypto/cipher_extra/e_chacha20poly1305.c
+++ b/src/crypto/cipher_extra/e_chacha20poly1305.c
@@ -41,6 +41,13 @@ static_assert(alignof(union evp_aead_ctx_st_state) >=
 
 static int aead_chacha20_poly1305_init(EVP_AEAD_CTX *ctx, const uint8_t *key,
                                        size_t key_len, size_t tag_len) {
+  // TODO(crbug.com/42290548): The x86_64 assembly depends on initializing
+  // |OPENSSL_ia32cap_P|. Move the dispatch to C. While we're here, it may be
+  // worth adjusting the assembly calling convention. The assembly functions do
+  // too much work right now. For now, explicitly initialize |OPENSSL_ia32cap_P|
+  // first.
+  CRYPTO_library_init();
+
   struct aead_chacha20_poly1305_ctx *c20_ctx =
       (struct aead_chacha20_poly1305_ctx *)&ctx->state;
 
diff --git a/src/crypto/fipsmodule/ec/p256-nistz.c b/src/crypto/fipsmodule/ec/p256-nistz.c
index cf0996382..277382046 100644
--- a/src/crypto/fipsmodule/ec/p256-nistz.c
+++ b/src/crypto/fipsmodule/ec/p256-nistz.c
@@ -612,6 +612,11 @@ static int ecp_nistz256_cmp_x_coordinate(const EC_GROUP *group,
 }
 
 DEFINE_METHOD_FUNCTION(EC_METHOD, EC_GFp_nistz256_method) {
+  // TODO(crbug.com/42290548): The x86_64 assembly depends on initializing
+  // |OPENSSL_ia32cap_P|. Move the dispatch to C. For now, explicitly initialize
+  // things.
+  CRYPTO_library_init();
+
   out->point_get_affine_coordinates = ecp_nistz256_get_affine;
   out->add = ecp_nistz256_add;
   out->dbl = ecp_nistz256_dbl;